Data/hora: 09/06/2024 10:38:26

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection
Autores: | Guardia,Ana Carolina; Stucchi,Raquel Silveira Bello; Milan,Arlete; Costa,Sandra Cecília Botelho; Boin,Ilka de Fátima Santana Ferreira.
Data: | 2014-04-01
Ano: | 2014
Palavras-chave: | Liver transplantation; Human herpesvirus 6; Cytomegalovirus; Liver donor biopsies.
Resumo: | Herpesvirus reactivation is common after liver transplantation.OBJECTIVE:Analyze the presence of cytomegalovirus (HCMV) and human herpesvirus-6 (HHV-6) DNA in liver donor biopsies, seeking to better understand issues involving human donor leukocyte antigens (HLA)-A, B and DR, as well as correlations with acute cellular rejection.METHODS:Fifty-nine liver transplantation patients were investigated for the presence of HCMV and HHV-6 DNA in liver donor biopsies, using the Nested-PCR technique. The clinical donor information and HLA matches were obtained from the São Paulo State Transplant System. The recipients' records regarding acute cellular rejection were studied.RESULTS:Seven (11.8%) biopsies were positive for HCMV DNA and 29 (49%) were positive for HHV-6 DNA. In 14 donors with HLA-DR 15 nine had HHV-6 DNA positive liver biopsy with a tendency for significant association (p=0.09), 22 recipients developed acute cellular rejection and 9/22 were positive for HLA-DR 15 (p=0.03; χ2=4.51), which was statistically significant in univariate analysis and showed a tendency after multivariate analysis (p=0.08).CONCLUSION:HHV-6 DNA was prevalent in liver donors studied as well as HLA-DR 15. These findings suggest that patients with HLA-DR 15 in liver donor biopsies develop more rejection after liver transplantation.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200220
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2013.07.007
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.18 n.2 2014
Fonte: | info:eu-repo/semantics/openAccess