Data/hora: 10/06/2024 16:58:05

Provedor de dados: 	55	
País: 	Brazil	
Título: 	An in vivo test to assess mefloquine 25 mg/kg for the treatment of uncomplicated falciparum malaria in Rondônia, Brazil	
Autores: 	Basano,S.A.; Bianco,A.; Taylor,W.R..J; Olliaro,P.; Camargo,L.M.A.	
Data: 	2006-08-01	
Ano: 	2006	
Palavras-chave: 	Malaria; Mefloquine; Amazon; Rondônia; Therapeutics.	
Resumo: 	Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400013	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702006000400013	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.10 n.4 2006	
Fonte: 	info:eu-repo/semantics/openAccess