Data/hora: 11/06/2024 01:12:42

Provedor de dados: | 55
País: | Brazil
Título: | Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China
Autores: | Gui,Qifeng; Yang,Yunmei; Zhang,Jiajia.
Data: | 2017-06-01
Ano: | 2017
Palavras-chave: | Mortality; Organ dysfunction; Older adults; Sepsis; Statins.
Resumo: | ABSTRACT This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups: a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for &lt;1 month prior to admission. A multivariate logistic regression analysis was performed to identify risk and protective factors for severe sepsis. A significantly lower incidence of organ dysfunction was found in the statin group, as compared with the non-statin group (13.3% vs 31.1%, respectively; p = 0.002), corresponding to adjusted rates ratio of 0.32 (95% confidence interval [CI], 0.13-0.75; p = 0.009). No significant difference was found between statin and non-statin groups in 30-day sepsis-related mortality (4.4% vs 10.2%, respectively; p = 0.109), incidence of intensive care unit admission (13.3% vs 16.8%, respectively; p = 0.469), or length of hospital stay (20.5 vs 25.9 days, respectively; p = 0.61). Statins significantly reduced the development of sepsis and infection-related organ dysfunction in hospitalized older Chinese patients but did not reduce 30-day mortality, ICU admission incidence, or length of hospital stay.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300255
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2016.12.008
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.21 n.3 2017
Fonte: | info:eu-repo/semantics/openAccess