Data/hora: 04/06/2024 10:47:10

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load	
Autores: 	Rathsam-Pinheiro,Regina Helena; Boa-Sorte,Ney; Grassi,Maria Fernanda Rios; Copello,Úrsula Cury; Rios,Karla Tayrine Silva Guimarães; Araújo,Thessika; Galvão-Castro,Bernardo.	
Data: 	2019-03-01	
Ano: 	2019	
Palavras-chave: 	HTLV-1; Keratoconjunctivitis sicca; Prevalence; Dry eye syndromes.	
Resumo: 	ABSTRACT  Background: The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described.  Purpose: To determine the prevalence and associated factors of HTLV-1/KCS in a large cohort of HTLV-1-infected individuals living in Salvador, Brazil.  Methods: A cross-sectional study was conducted between June 2004 and September 2017 at the Integrative and Multidisciplinary Center for HTLV in Salvador, Bahia-Brazil. Data from 758 HTLV-1-infected patients was collected. A complete ophthalmologic examination was performed in both eyes. Lacrimal function was evaluated by breakup time, Rose Bengal and Schirmer I Tests. KCS diagnosis was considered in the presence of at least two out of three positive tests. HTLV-1 proviral load Crude and Adjusted Prevalence Rates (PR) with 95% Confidence Intervals (95% CI) were estimated using multivariate Poisson Regression with robust error variance.  Results: The overall prevalence of KCS was 31.7%, with higher rates observed in HTLV-1-associated myelopathy/tropical spastic paraparesis patients (crude PR: 1.84; CI95%: 1.50-2.26) even after adjusting for age, sex, time of HTLV-1 diagnosis and schooling (adjusted PR: 1.63; CI95%: 1.31-2.02). Proviral load, low corrected visual acuity, burning and/or pain and itching were all significantly higher in patients with KCS.  Conclusion: Burning and/or pain and itching and low corrected visual acuity were the most common alterations of HTLV-1/KCS. High Proviral load was found to be associated with the presence of KCS. It is strongly recommended that HTLV-1 patients undergo periodic ophthalmologic examination to promote the early diagnosis of KCS and prevent the consequences associated with dry eye disease.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200095	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2019.04.002	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.23 n.2 2019	
Fonte: 	info:eu-repo/semantics/openAccess