Data/hora: 04/06/2024 13:53:59

Provedor de dados: | 55
País: | Brazil
Título: | Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
Autores: | Angelo,Ana Luiza Dias; Angelo,Camila Dias; Torres,Alex José Leite; Ramos,André Maurício Costa; Lima,Márcia; Netto,Eduardo Martins; Brites,Carlos.
Data: | 2007-10-01
Ano: | 2007
Palavras-chave: | Lymphocyte counts; CD4 counts; AIDS.
Resumo: | This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 &lt; 200 cells/mm³) and patients with CD4 &lt; 350 cells/mm³ (Brazilian threshold value of CD4 count to define AIDS). We evaluated TLC and CD4+ cells count of 1,174 HIV-infected patients, in Salvador, Brazil, from May 2003 to September 2004. CD4+ cell counts were performed by flow cytometry, and TLC was measured with an automated hematological counter. The mean CD4 count was 430 cells/mm³ (range: 4 to 2,531 cells/mm³). Mean TLC was 1,900 cells/mm³ (range: 300 to 6,200 cells/mm³). Using a threshold value of 1,000 cells/mm³ for TLC, the positive predictive value (PPV) was 77% for CD4 &lt; 200 cells/mm³, but the sensitivity was only 29%, while the negative predictive value (NPV) was 88%, with 98% specificity. Similar findings were observed for CD4 count &lt; 350. Using the same threshold value of 1,000 cells/mm³ for TLC, sensitivity was 14%, and specificity 99% (PPV= 94%; NPV=62%). In 70/1,510 (5%) of the samples the sum of CD4 and CD8 cell counts was greater than the TLC and in 27% (419/1,510) this sum was below 65% of the TLC. TLC has a high specificity to identify patients for prophylaxis, but a quite low sensitivity. It is not useful as an alternative to CD4+ T-cell counts as a marker in HIV-infected patients.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500005
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702007000500005
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.11 n.5 2007
Fonte: | info:eu-repo/semantics/openAccess