Data/hora: 03/06/2024 18:04:55

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Comparison among the BED capture enzyme immunoassay test and AxSYM avidity index assay for determining recent HIV infection and incidence in two Voluntary Counselling and Testing Centres in Northeast Brazil
Autores: | Salustiano,Daniela Medeiros; Lima,Kledoaldo Oliveira de; Cavalcanti,Ana Maria Salustiano; Diaz,Ricardo Sobhie; Lacerda,Heloisa Ramos.
Data: | 2014-08-01
Ano: | 2014
Palavras-chave: | HIV; Recent infection; Avidity index assay; BED-CEIA.
Resumo: | The aims of this study were to compare the automated AxSYM avidity assay index with the BED capture enzyme immunoassay test and to calculate the HIV-1 incidence using the BED capture enzyme immunoassay and AxSYM avidity assay index algorithms within a population seeking the Voluntary Counselling and Testing Centres in two municipalities in the Metropolitan Region of Recife, Northeast of Brazil. An analysis was conducted in 365 samples that tested positive for HIV infection from frozen serum collected during the period 2006-2009. There was a similar proportion of males and females; most patients were heterosexual (86%) with a median age of 29 years. Of the 365 samples, 102 (28%) and 66 (18.1%) were identified as recent infections by BED capture enzyme immunoassay and AxSYM avidity assay index, respectively. The HIV-1 total incidence in the BED capture enzyme immunoassay and AxSYM avidity assay index algorithms were: 0.79 (95% CI: 0.60-0.98) and 0.34 (95% CI: -0.04 to 0.72), respectively. Incidence was higher among men. There was good agreement between the tests, with a kappa of 0.654 and a specificity of 95.8%. AxSYM avidity assay index may be helpful in improving the quality of the estimates of recent HIV infection and incidence, particularly when used in a combined algorithm with BED capture enzyme immunoassay.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400449
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2014.03.001
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.18 n.4 2014
Fonte: | info:eu-repo/semantics/openAccess