Data/hora: 03/06/2024 03:49:48

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Endothelial function and cardiovascular diseases in HIV infected patient
Autores: | Andrade,Ana Cristina O.; Cotter,Bruno R.
Data: | 2006-04-01
Ano: | 2006
Palavras-chave: | Human immunodeficiency virus; Endothelial dysfunction; Endothelial adhesion molecules; Antiretroviral therapy; Cardiovascular risk factors; Atherosclerosis; Coronary heart disease.
Resumo: | The HIV epidemic has dramatically changed the paradigm for the development of drug therapy in the last 15 years. The goal is now not only to provide an effective reduction of plasma viremia , but also to reconstitute the immune deficiency due to the progression of the disease. Significant problems with the metabolism of sugars and lipids lead to the appearance of well-documented disorders such as insulin resistance, abnormalities in lipid metabolism and lipodystrophy in those patients on prolonged therapy with antiretrovirals. The question of whether or not HAART-associated lipid disorders contribute to the premature development of coronary artery disease is of major importance for the HIV community. Endothelial injury is associated with disease-related biochemical abnormalities that are implicated in HIV pathogenesis. The exploration of endothelial function began in the early 1980s at the start of the epidemic. The study of endothelial function in HIV infection and its modifications by HAART is an exciting new field in clinical research; in this review the available information on cardiovascular diseases associated with HIV infection and its treatment are discussed.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200012
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702006000200012
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.10 n.2 2006
Fonte: | info:eu-repo/semantics/openAccess