Data/hora: 04/06/2024 07:15:48

Provedor de dados: | 55
País: | Brazil
Título: | Acute HIV infection with rapid progression to AIDS
Autores: | Silva,Marcio de Oliveira; Bastos,Milena; Martins Netto,Eduardo; Gouvea,Nancy Alves de Lima; Torres,Alex Jose Leite; Kallas,Esper; Watkins,David I; Altfeld,Marcus; Brites,Carlos.
Data: | 2010-06-01
Ano: | 2010
Palavras-chave: | HIV; Acute infection; Progression; AIDS.
Resumo: | Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
Tipo: | Info:eu-repo/semantics/report
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702010000300016
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.14 n.3 2010
Fonte: | info:eu-repo/semantics/openAccess