Data/hora: 03/06/2024 19:03:51

Provedor de dados: | 55
País: | Brazil
Título: | Tuberculosis incidence among people living with HIV/AIDS with virological failure of antiretroviral therapy in Salvador, Bahia, Brazil
Autores: | Rebouças,Monaliza Cardozo; Silva,Márcio Oliveira da; Haguihara,Tatiana; Brites,Carlos; Martins Netto,Eduardo.
Data: | 2017-10-01
Ano: | 2017
Palavras-chave: | Tuberculosis; Virological failure; HIV infection.
Resumo: | Abstract Antiretroviral therapy for HIV has led to increased survival of HIV-infected patients. However, tuberculosis remains the leading opportunistic infection and cause of death among people living with HIV/AIDS. Tuberculosis has been shown to be a good predictor of virological failure in this group. This study aimed to evaluate the incidence of tuberculosis and its consequences among individuals diagnosed with virological failure of HIV. This was a retrospective cohort study involving people living with HIV/AIDS being followed-up in an AIDS reference center in Salvador, Bahia, Brazil. Individuals older than 18 years with HIV infection on antiretroviral therapy for at least six months, diagnosed with virological failure (HIV-RNA greater than or equal to 1000 copies/mL), from January to December 2013 were included. Tuberculosis was diagnosed according to the criteria of the Brazilian Society of Pneumology. Fourteen out of 165 (8.5%) patients developed tuberculosis within two years of follow-up (incidence density = 4.1 patient-years). Death was directly related to tuberculosis in 6/14 (42.9%). A high incidence and tuberculosis-related mortality was observed among patients with virological failure. Diagnosis of and prophylaxis for tuberculosis in high-incidence countries such as Brazil is critical to decrease morbidity and mortality in people living with HIV/AIDS.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500562
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2017.05.005
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.21 n.5 2017
Fonte: | info:eu-repo/semantics/openAccess