Data/hora: 16/06/2024 10:17:04

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Prevalence of HBV genotypes in South American immigrants affected by HBV-related chronic active hepatitis
Autores: | Palumbo,Emilio; Scotto,Gaetano; Faleo,Giuseppina; Cibelli,Donatella Concetta; Angarano,Gioacchino.
Data: | 2007-06-01
Ano: | 2007
Palavras-chave: | HBV genotypes; Chronic hepatitis B; Immigrants; HBsAg; Viral genome.
Resumo: | This study evaluated the prevalence of HBV infection in a population of South American immigrants in Italy and to determine in patients with detectable serum HBV-DNA the HBVgenotypes. Between April 2005 and April 2006 a total of 130 South American immigrants were tested for HBsAg. In HBsAg positive patients the biochemical and virological activity of infection and the possible presence of co-infections (HCV, HDV, HIV) were evaluated. In patients with detectable serum HBV DNA, the HBV genotype was determined by INNOLiPA. Among the 130 subjects tested, 14 (10.7%) resulted HBsAg positive. All were men, with a mean age of 22 years (range 19-37) and 12 (85.7 %) came from Brazil, while 2 (14.3%) came from Ecuador. All patients infected by HBV had elevated alanine-aminotransferase serum levels (mean level was 127 IU/L, range 74-312) and serum HBV DNA detectable by PCR-Real Time (mean level 1,037,652 copies/mL, range 19,876-1,377,648). Genotype distribution was as follow: genotype D, 9 (64.2%), genotype A, 5 (35.8%). All patients infected by genotype D came from Brazil, while among the patients infected by genotype A, three came from Brazil and two from Ecuador. Our study evidences a moderate prevalence of HBV-infection in South American immigrants with the identification of two genotypes, D and A. These genotypes are not the most prevalent in the South America and this is probably the expression of a possible geographical redistribution of HBV genotypes.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300002
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702007000300002
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.11 n.3 2007
Fonte: | info:eu-repo/semantics/openAccess