Data/hora: 04/06/2024 06:33:00

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru
Autores: | Llanos-Cuentas,A.; Campos,P.; Clendenes,M.; Canfield,C. J.; Hutchinson,D. B. A.
Data: | 2001-04-01
Ano: | 2001
Palavras-chave: | Malarone; Atovaquone; Proguanil; Chloroquine resistance; Peru.
Resumo: | The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru. Patients were initially randomized to receive 1,000 mg atovaquone and 400 mg proguanil hydrochloride daily for 3 days (n=15) or 1,500 mg chloroquine (base) over a 3 day period (n=14) (phase 1). The cure rate with chloroquine was lower than expected and patients were subsequently randomized to receive a single dose of 75 mg pyrimethamine and 1,500 mg sulfadoxine (n=9) or atovaquone/proguanil as before (n=5) (phase 2). In phase 1, atovaquone/proguanil was significantly more effective than chloroquine (cure rate 100% [14/14] versus 8% [1/13], P&lt;0.0001). In phase 2, atovaquone/proguanil and pyrimethamine/sulfadoxine were both highly effective (cure rates 100% [5/5] and 100% [7/7]). There were no significant differences between treatment groups in parasite or fever clearance times. Adverse events were typical of malarial symptoms and did not differ significantly between groups. Overall efficacy of atovaquone/proguanil was 100% for treatment of acute falciparum malaria in a region with a high prevalence of chloroquine resistance.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200004
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702001000200004
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.5 n.2 2001
Fonte: | info:eu-repo/semantics/openAccess