Data/hora: 12/06/2024 07:17:38

Provedor de dados: | 55
País: | Brazil
Título: | Renal involvement in leptospirosis: new insights into pathophysiology and treatment
Autores: | Cerqueira,Thaís Bandeira; Athanazio,Daniel Abensur; Spichler,Anne Stambovsky; Seguro,Antônio Carlos.
Data: | 2008-06-01
Ano: | 2008
Palavras-chave: | Leptospirosis; Kidney failure; Acute; Physiopathology; Dialysis.
Resumo: | Acute renal failure (ARF) is one of the most common complications of leptospirosis although the causal mechanisms are still unclear. Diverse mechanisms are implicated in leptospiral nephropathy and new data supports the role of peculiar ion transport defects. Besides antibiotic therapy, ARF management in leptospirosis requires dialytic therapy which is most efficient when started early. Dialysis is the standard supportive therapy even though recent evidence suggests clinical benefit from alternative treatments such as plasmapheresis and hemofiltration. Renal recovery is achieved soon after clinical improvement. The comprehension of the primary mechanisms of renal dysfunction will be helpful in the development of additional therapeutic tools for improving supportive therapy for leptospiral nephropathy. This review discusses new insights into mechanisms implicated in leptospiral ARF and recent advances in treatment.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300016
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702008000300016
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.12 n.3 2008
Fonte: | info:eu-repo/semantics/openAccess