Data/hora: 09/06/2024 14:47:32

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Revisiting the Rich's formula: an update about granulomas in human tuberculosis
Autores: | Coelho Filho,João Carlos; Takenami,Iukary; Arruda,Sérgio.
Data: | 2013-04-01
Ano: | 2013
Palavras-chave: | Rich's formula; Tuberculosis; Immunopathogenesis; Granuloma; Hypersensitivity.
Resumo: | The formula proposed by Rich in 1951 explained the formation in a tuberculous lesion in a period that was unknown cellular functions, cytokines and other immunological aspects involved in granuloma formation by tuberculosis; its components are assembled conceptually to explain the pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. In this manuscript, we report an update of Rich's formula based on the new and old concepts about pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. Current knowledge allows us to conclude that the balance between the characteristics of the bacillus and host protective response is necessary to indicate the outcome of pathogenesis, infection or active disease and the necrosis degree of the tuberculosis lesion.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200017
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2013.01.006
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.17 n.2 2013
Fonte: | info:eu-repo/semantics/openAccess