Data/hora: 08/06/2024 09:37:11

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Progressive disseminated histoplasmosis: a systematic review on the performance of non-culture-based diagnostic tests
Autores: | Falci,Diego R.; Hoffmann,Elias R.; Paskulin,Diego D.; Pasqualotto,Alessandro C.
Data: | 2017-02-01
Ano: | 2017
Palavras-chave: | Disseminated histoplasmosis; Non-culture; Enzyme immunoassay; Diagnostic tests.
Resumo: | Abstract The diagnosis of progressive disseminated histoplasmosis is often a challenge to clinicians, especially due to the low sensitivity and long turnaround time of the classic diagnostic methods. In recent years, studies involving a variety of non-culture-based diagnostic tests have been published in the literature. We performed a systematic review by selecting studies evaluating non-culture-based diagnostic methods for progressive disseminated histoplasmosis. We searched for articles evaluating detection of antibody, antigens, as well as DNA-based diagnostic methods. A comprehensive PUBMED, Web of Science, and Cochrane Library search was performed between the years 1956 and 2016. Case reports, review articles, non-human models and series involving less than 10 patients were excluded. We found 278 articles and after initial review 18 articles were included: (12) involved antigen detection methods, (4) molecular methods, and (2) antibody detection methods. Here we demonstrate that the pursuit of new technologies is ultimately required for the early and accurate diagnosis of disseminated histoplasmosis. In particular, urinary antigen detection was the most accurate tool when compared with other diagnostic techniques.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100007
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2016.09.012
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.21 n.1 2017
Fonte: | info:eu-repo/semantics/openAccess