Data/hora: 11/06/2024 06:52:05

Provedor de dados: 	Brazilian Journal of Infectious Diseases	
País: 	Brazil	
Título: 	Incidence of antiretroviral adverse drug reactions in pregnant women in two referral centers for HIV prevention of mother-to-child-transmission care and research in Rio de Janeiro, Brazil	
Autores: 	Santini-Oliveira,Marilia; Friedman,Ruth Khalili; Veloso,Valdilea Gonçalves; Cunha,Cynthia Braga; Pilotto,José Henrique; Marins,Luana Monteiro Spindola; João,Esaú Custódio; Torres,Thiago Silva; Grinsztejn,Beatriz.	
Data: 	2014-08-01	
Ano: 	2014	
Palavras-chave: 	HIV; Antiretroviral; Prevention of mother-to-child transmission; Adverse drug reaction; Toxicity.	
Resumo: 	Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection remains an important cause of new HIV infections worldwide, especially in low and middle-resource limited countries. Safety data from studies involving pregnant women and prenatal antiretroviral (ARV) exposure are still needed once these studies are often small and with a limited duration to assess adverse drug reactions (ADR). The aim of this study was to estimate the incidence of ADR related to the use of antiretroviral therapy (ART) in pregnant women in two referral centers in Rio de Janeiro State. A prospective study was carried out from February 2005 to May 2006. Women were classified according to their ART status during pregnancy diagnosis: ARV-experienced (ARTexp) or ARV-naïve (ARTn). Two hundred fourteen HIV-infected pregnant women were included: 36 ARTexp and 178 ARTn. ARTexp women have not experienced ADR. Among ARTn, 20.2% presented ADR. Incidence rate of ADR was 70.8 per 1000 person-months and the most common ADRs observed were: gastrointestinal (belly or abdominal cramps, diarrhea, nausea and vomit) in 16.3%, cutaneous (pruritus and rash) in 6.2%, anemia (2.2%) and hepatitis (1.7%). The frequency of obstetrical complications, pre-term delivery, low birth weight and birth abnormalities was low in this population. ADRs ranged from mild to moderate intensity, none of them being potentially fatal. Only in a few cases it was necessary to discontinue ART. In conclusion, the high effectiveness of ARV for HIV prevention of MTCT (PMTCT) overcomes the risk of ADR.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400372	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2013.11.008	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.18 n.4 2014	
Fonte: 	info:eu-repo/semantics/openAccess