Data/hora: 07/06/2024 00:41:15

Provedor de dados: 	Brazilian Journal of Infectious Diseases	
País: 	Brazil	
Título: 	Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis	
Autores: 	Ávila,Renata Eliane de; Carmo,Ricardo Andrade; Farah,Kátia de Paula; Teixeira,Antônio Lúcio; Coimbra,Lucas Viana; Antunes,Carlos MaurÃ­cio de Figueiredo; Lambertucci,José Roberto.	
Data: 	2010-08-01	
Ano: 	2010	
Palavras-chave: 	Liver fibrosis; Hyaluronic acid; End-stage renal disease; Haemodialysis; Hepatitis C.	
Resumo: 	BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR &gt; F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively. CONCLUSION: HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400004	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702010000400004	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.14 n.4 2010	
Fonte: 	info:eu-repo/semantics/openAccess