Data/hora: 04/06/2024 08:43:02

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Low frequency of hypersensitivity reactions to abacavir in HIV infected patients in a referral center in Bahia, Brazil	
Autores: 	Barreto,Raphael Gusmão; Brites,Carlos.	
Data: 	2019-08-01	
Ano: 	2019	
Palavras-chave: 	Hypersensitivity; Antiretroviral; HIV; Abacavir.	
Resumo: 	Abstract Abacavir can cause a multi-systemic hypersensitivity reaction (HSR) in 5-8% of the patients, which is related to HLA-B*57-01 allele. In Brazil, the HLA-B*57-01 screening test became available only in March 2018, several years after abacavir was in use. In this retrospective study we reviewed medical charts of all patients receiving an abacavir-containing regimen to evaluate the frequency of HSR in patients followed at a referral center in Salvador, Brazil. A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). Only one patient developed HSR (incidence: 0.52%). The main reasons for abacavir-containing antiretroviral therapy discontinuation were virological failure (28%), adverse effects to other components of the regimen (25%), and simplification of therapy (16%). The low incidence of HSR to abacavir does not support the use of HLA-B*57-01 screening test, in Salvador, Brazil.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400268	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2019.06.003	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.23 n.4 2019	
Fonte: 	info:eu-repo/semantics/openAccess