Data/hora: 09/06/2024 11:41:51

Provedor de dados: | 55
País: | Brazil
Título: | Low frequency of hypersensitivity reactions to abacavir in HIV infected patients in a referral center in Bahia, Brazil
Autores: | Barreto,Raphael Gusmão; Brites,Carlos.
Data: | 2019-08-01
Ano: | 2019
Palavras-chave: | Hypersensitivity; Antiretroviral; HIV; Abacavir.
Resumo: | Abstract Abacavir can cause a multi-systemic hypersensitivity reaction (HSR) in 5-8% of the patients, which is related to HLA-B*57-01 allele. In Brazil, the HLA-B*57-01 screening test became available only in March 2018, several years after abacavir was in use. In this retrospective study we reviewed medical charts of all patients receiving an abacavir-containing regimen to evaluate the frequency of HSR in patients followed at a referral center in Salvador, Brazil. A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). Only one patient developed HSR (incidence: 0.52%). The main reasons for abacavir-containing antiretroviral therapy discontinuation were virological failure (28%), adverse effects to other components of the regimen (25%), and simplification of therapy (16%). The low incidence of HSR to abacavir does not support the use of HLA-B*57-01 screening test, in Salvador, Brazil.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400268
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2019.06.003
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.23 n.4 2019
Fonte: | info:eu-repo/semantics/openAccess