Data/hora: 04/06/2024 17:46:31

Provedor de dados: | 55
País: | Brazil
Título: | Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis
Autores: | Uchoa,Breno Kristoffer Beleza; Albério,Carlos Augusto Abreu; Pinto,Ana Carla Godinho; Lucena,Stefania de Medeiros Araujo; Vieira,José Luiz Fernandes.
Data: | 2019-03-01
Ano: | 2019
Palavras-chave: | Infectious disease; Tuberculosis; Rifampicin.
Resumo: | ABSTRACT Rifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifampicin are sustained above 0.5 µg/mL in patients with tuberculosis using 600 mg/day. Rifampicin was measured in plasma by high-performance liquid chromatography and a sputum smear microscopy was performed in all days of the study. A total of 44 male patients completed the study. On days 31, 61 and 91, the mean plasma concentrations of rifampicin were 0.6 (0.5) µg/mL, 0.55 (0.5) µg/mL and 0.46 (0.4) µg/mL. There was a high variation of rifampicin levels leading to a high percentage of samples with concentrations below 0.5 µg/mL. There was no significant association between the frequency of samples with drug levels below 0.5 µg/mL with the conversion of the sputum microscopy. These data suggest that pre-doses samples offer limited information on the exposure of M. tuberculosis to rifampicin.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200130
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2019.05.001
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.23 n.2 2019
Fonte: | info:eu-repo/semantics/openAccess