Data/hora: 04/06/2024 18:24:59

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women	
Autores: 	Firmino,Alisson de Aquino; Martins,Adenilda Lima Lopes; Gois,Luana Leandro; Paixão,Taiane Silva; Batista,Everton da Silva; Galvão-Castro,Bernardo; Grassi,Maria Fernanda Rios.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	HTLV-1; Inflammatory cytokines; Proviral load; Cervicovaginal cytopathology.	
Resumo: 	ABSTRACT  Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women.  Methods: HTLV-1-infected and uninfected women were selected at the Centro de Atendimento ao Portador de HTLV in Salvador-Brazil. None of the included HTLV-1-infected women reported any HTLV-1-associated diseases. All volunteers underwent gynecological examination to collect cervicovaginal fluid. Cytokine quantification was performed using the Cytometric Bead Array (CBA) Human Th1/Th2/Th17 kit. Light microscopy was used to evaluate cervicovaginal cytopathology. In addition, proviral load in cervicovaginal fluid and peripheral blood was measured by real-time quantitative polymerase chain reaction.  Results: 112 women (63 HTLV-1-infected and 49 uninfected) were evaluated. No differences were found with respect to cytopathological cervicovaginal findings between the groups. IL-2, TNF, IL-4, IL-10, and IL-17 levels were significantly higher in cervicovaginal fluid of the HTLV-1-infected women than in uninfected women (p &lt; 0.05). Conversely, IFN-γ was found to be lower in the HTLV-1-infected women (p &lt; 0.001) compared to uninfected individuals. Cervicovaginal proviral load was detectable in 53% of the HTLV-1-infected women and was found to be consistently lower than the proviral load in peripheral blood.  Conclusions: HTLV-1 infection induces immune activation in cervicovaginal environment, characterized by elevated concentrations of Th1, Th2, and IL17 in the cervicovaginal fluid.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100027	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2019.02.001	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.23 n.1 2019	
Fonte: 	info:eu-repo/semantics/openAccess