Data/hora: 16/06/2024 00:32:39

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Methemoglobinemia and dapsone levels in patients with leprosy	
Autores: 	Vieira,Jose Luiz Fernandes; Riveira,Juan Gonzalo Bardarez; Martins,Ana de Nazaré Silva; Silva,Jorge Pereira da; Salgado,Claudio Guedes.	
Data: 	2010-06-01	
Ano: 	2010	
Palavras-chave: 	Methahemoglobinemia; Dapsone; Leprosy.	
Resumo: 	The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300022	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702010000300022	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.14 n.3 2010	
Fonte: 	info:eu-repo/semantics/openAccess