Data/hora: 10/06/2024 18:25:20

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Fluconazole prophylaxis in preterm infants: a systematic review
Autores: | Rios,Juliana Ferreira da Silva; Camargos,Paulo Augusto Moreira; Corrêa,Luísa Petri; Romanelli,Roberta Maia de Castro.
Data: | 2017-06-01
Ano: | 2017
Palavras-chave: | Antifungal; Candida; Fluconazole prophylaxis; Preterm infants.
Resumo: | ABSTRACT  Objective: This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis.  Methods: This is a systematic review with search at databases: PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The keywords used were: "Antifungal", "Candida" "Fluconazole prophylaxis" and "Preterm infants".  Results: Invasive Candidiasis was evaluated in all the twelve items. In eleven of them, there was a statistically significant difference between the groups receiving prophylactic fluconazole, with lower frequency of Invasive Candidiasis, compared to placebo or no prophylaxis group. Colonization by Candida species was also evaluated in five studies; four of them presented statistically lower proportion of colonization in patients with Fluconazole prophylaxis, compared to placebo or no drugs. In one study, there was a significant difference, favoring the use of fluconazole, and reduction of death.  Conclusion: Studies indicate the effectiveness of prophylaxis with fluconazole, with reduction in the incidence of colonization and invasive fungal disease. The benefits of prophylaxis should be evaluated considering the incidence of candidiasis in the unit, the mortality associated with candidiasis, the safety and toxicity of short and long-term medication, and the potential for development of resistant pathogens.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300333
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2017.01.008
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.21 n.3 2017
Fonte: | info:eu-repo/semantics/openAccess