Data/hora: 08/06/2024 06:53:20

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Combined pegylated interferon and ribavirin for the management of chronic hepatitis C in a prison setting
Autores: | Sabbatani,Sergio; Giuliani,Ruggero; Manfredi,Roberto.
Data: | 2006-08-01
Ano: | 2006
Palavras-chave: | Chronic hepatitis C; Pegylated interferon; Ribavirin; Management; Inmates; Prison.
Resumo: | The elevated frequency of chronic hepatitis C virus (HCV) infection found among prison inmates, and the availability of improved pharmacological cure for this potentially life-threatening disorder, make investigations conducted in this somewhat neglected area very relevant, since only a few, open-label experiences have been reported till now. In the metropolitan prison of Bologna (Italy), HCV seroprevalence was found to be over 31% in 2003, so that a pilot feasibility study based on treatment with pegylated interferon plus ribavirin was initiated, after careful counseling carried out by a joint commission of health care personnel of the correctional facility and infectious diseases consultants. Thirty-nine patients were enrolled, and despite expected dropouts due to difficulty in maintaining the same level of counseling pressure over time, and the particularly unfavorable climatic conditions during Summer 2003, a sustained virological response was obtained for 8 out of the 21 patients who remained evaluable after the first three month follow-up, although we need to take into account that a high percentage of subjects (67%) were selected for therapy due to their favorable HCV genotypes (types 2 and 3). Our preliminary experience shows that an intrinsically complicated therapy, such as the administration of pegylated interferon plus ribavirin, can attain a relatively high success rate, even in a very unfavorable and uncomfortable context, such as a prison, where only enforced counseling, active participation of institutional health care operators, and patient's willingness to maintain an elevated level of co-operation and adherence, can overcome most structural and relational difficulties.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400012
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702006000400012
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.10 n.4 2006
Fonte: | info:eu-repo/semantics/openAccess