Data/hora: 02/06/2024 07:27:31

Provedor de dados: | 55
País: | Brazil
Título: | Fluconazole susceptibility of Brazilian Candida isolates assessed by a disk diffusion method
Autores: | Colombo,Arnaldo L.; Matta,Daniel da; Almeida,Leila Paula de; Rosas,Robert.
Data: | 2002-06-01
Ano: | 2002
Palavras-chave: | Candida; Fluconazole; Antifungal resistance; Disk diffusion method.
Resumo: | The increasing magnitude of antifungal resistance as well as the advent of new antifungal drugs has generated a renewed interest in fungal susceptibility testing. We used a previously described disk diffusion method to evaluate the susceptibility profile of a large collection of recent clinical Candida spp. isolates against fluconazole. A total of 1,784 yeast isolates were tested, including the following species: Candida albicans (1,036), C. tropicalis (279), C. parapsilosis (202), C. glabrata (119), C. guilliermondii (90), C. krusei (32), C. lusitaniae (7), Candida spp. (14) and other yeasts (5). Susceptibility ranking to fluconazole obtained with all yeasts tested was: C. parapsilosis &lt;FONT FACE=Symbol&gt;@&lt;/FONT&gt; C. tropicalis &lt;FONT FACE=Symbol&gt;@&lt;/FONT&gt; C. guilliermondii &gt; C. glabrata &gt; C. krusei. The majority (94%) of all yeast isolates tested were susceptible to fluconazole. Isolates of C. glabrata and C. krusei exhibited the highest rate of DDS/resistance among all isolates tested but they represented only 9% of all yeasts routinely sent to our lab. Careful periodical surveillance is needed in order to identify any changes in the susceptibility patterns of fluconazole with the increased use of this antifungal agent in Brazilian tertiary care hospitals.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300003
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702002000300003
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.6 n.3 2002
Fonte: | info:eu-repo/semantics/openAccess