Data/hora: 11/06/2024 04:39:44

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | HBV epidemiology and genetic diversity in an area of high prevalence of hepatitis B in southern Brazil
Autores: | Paoli,Juliana de; Wortmann,André Castagna; Klein,Mirelli Gabardo; Pereira,Vagner Reinaldo Zingalli Bueno; Cirolini,Adriana Maria; Godoy,Bibiane Armiliato de; Fagundes,Nelson Jurandi Rosa; Wolf,Jonas Michel; Lunge,Vagner Ricardo; Simon,Daniel.
Data: | 2018-08-01
Ano: | 2018
Palavras-chave: | HBV infection; Epidemiology; HBV genotypes; Risk factor; Transmission; Cross-sectional studies.
Resumo: | ABSTRACT  Background Hepatitis B virus (HBV) infection is a major public health problem in Brazil. HBV endemicity is usually moderate to low according to geographic regions, and high prevalence of this virus has been reported in people of some specific Brazilian counties, including those with a strong influence of Italian colonization in southern Brazil. Analysis of HBV diversity and identification of the main risk factors to HBV infection are necessary to understand hepatitis B epidemiology in these high prevalence regions in southern Brazil.  Objective To investigate epidemiological characteristics and HBV genotypes and subgenotypes circulating in a specific city with high HBV prevalence.  Methods A cross-sectional study was performed with 102 HBV chronically infected individuals, recruited in reference outpatient clinics for viral hepatitis in a city of high HBV prevalence (Bento Gonçalves) in Rio Grande do Sul state, Brazil between July and December 2010. Socio-demographic, clinical and behavior-related variables were collected in a structured questionnaire. HBV serological markers (HBsAg, anti-HBc), viral load, genotypes/subgenotypes and drug resistance were evaluated and comparatively analyzed among all patients.  Results The HBV infected subjects had a mean age of 44.9 (±12.2) years, with 86 patients (84.3%) reporting to have a family history of HBV infection, 51 (50.0%) to share personal objects, and were predominantly of Italian descendants (61; 64.9%). There was a predominance of genotype D (49/54; 90.7%), but genotype A was also detected (5/54; 9.3%). Subgenotypes D1 (1; 4.7%), D2 (3; 14.3%), and D3 (17; 81.0%) were identified. LAM-resistant mutation (rtM204I) and ADV-resistant mutations (rtA181V) were detected in only one patient each.  Conclusions These results demonstrate a pivotal role of intrafamilial transmission for HBV spreading in this population. Furthermore, there is a high prevalence of HBV genotype D in this region.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400294
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2018.06.006
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.22 n.4 2018
Fonte: | info:eu-repo/semantics/openAccess