Data/hora: 10/06/2024 17:22:35

Provedor de dados: | Brazilian Journal of Infectious Diseases
País: | Brazil
Título: | Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal
Autores: | Baral,Pankaj; Neupanea,Sanjiv; Shresthac,Basudha; Ghimirea,Kashi Ram; Marasinia,Bishnu Prasad; Lekhaka,Binod.
Data: | 2013-04-01
Ano: | 2013
Palavras-chave: | AmpC β-lactamase; Enterobacteriaceae; Antibiotic resistance.
Resumo: | Limited information is available regarding AmpC β-lactamase (ABL)-producing Enterobacteriaceae compared to extended-spectrum β-lactamase-producing enterobacteria. Since ABL-producing organisms are often resistant to multiple antimicrobial agents, therapeutic options against these pathogens are limited. Among 230 clinical Enterobacteriaceae isolates, 64 (27.8%) were found to produce ABL in our study. Escherichia coli (83.9%) was a predominant pathogen, followed by Citrobacter freundii (5.2%). A significant proportion of ABL-producing isolates (81.3%) were found to be multidrug resistant against commonly used antibiotics. Univariate analysis showed that prior history of taking antibiotics (odds ratio [OR], 5.278; confidence interval [CI], 2.838-9.817; p &lt; 0.001) and being inpatients (OR, 4.587; CI, 2.132-9.9; p &lt; 0.001) were associated with ABL positivity. Regular antimicrobial resistance surveillance for ABL-producing Enterobacteriaceae is warranted for proper antimicrobial treatment strategy and policy making due to ABL-positive infections.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200022
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2012.09.012
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.17 n.2 2013
Fonte: | info:eu-repo/semantics/openAccess