Data/hora: 16/06/2024 09:24:25

Provedor de dados: 	Brazilian Journal of Infectious Diseases	
País: 	Brazil	
Título: 	Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America	
Autores: 	Vidal,Jose E.; Oliveira,Augusto C. Penalva de; Dauar,Rafi F.; Boulware,David R.	
Data: 	2013-06-01	
Ano: 	2013	
Palavras-chave: 	Cryptococcal meningitis; Cryptococccosis; Epidemiology; Diagnosis; Treatment; Mortality; Latin America.	
Resumo: 	Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of intracranial pressure and induction therapy with antifungal combination. Implementation of these strategies can reduce cryptococcal-related deaths, improve care, and reduce healthcare costs.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2012.10.020	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.17 n.3 2013	
Fonte: 	info:eu-repo/semantics/openAccess