Data/hora: 03/06/2024 03:10:49

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Interleukin-12 as a biomarker of the beneficial effects of food restriction in mice receiving high fat diet or high carbohydrate diet
Autores: | de Almeida-Souza,C.B.; Antunes,M.M.; Godoy,G.; Schamber,C.R.; Silva,M.A.R.C.P.; Bazotte,R.B.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Pro-inflammatory cytokines; Anti-inflammatory cytokines; Serum cytokines; Caloric restriction; Nutrition.
Resumo: | The impact of food restriction (FR) during 56 days on serum levels of cytokines in mice fed a high-fat diet (HFD) or high-carbohydrate diet (HCD) were evaluated. The amount of food was reduced 50% for HFD-FR and HCD-FR groups compared to mice receiving free access to HFD (HFD group) or HCD (HCD group). We quantified the serum levels of basic fibroblast growth factor, granulocyte-macrophage colony-stimulating factor, inducible protein 10, interferon γ, interleukin 1α (IL-1α), IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, keratinocyte chemoattractant, macrophage inflammatory protein-1α, monocyte chemotactic protein 1, monokine induced by IFN-γ, and tumor necrosis factor α. Only IL-12 levels were lower (P&lt;0.05), for both HFD-FR (HFD-FR vs HFD) and HCD-FR (HCD-FR vs HCD). Therefore, IL-12 levels could be considered a biological marker of the beneficial effects of FR.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200606
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20187900
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.51 n.12 2018
Fonte: | info:eu-repo/semantics/openAccess