Data/hora: 04/06/2024 03:33:04

Provedor de dados: | 56
País: | Brazil
Título: | Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signalling pathway in memory consolidation of an avoidance task in rats
Autores: | Bernabeu,R.; Cammarota,M.; Izquierdo,I.; Medina,J.H.
Data: | 1997-08-01
Ano: | 1997
Palavras-chave: | Glutamate AMPA receptors; CAMP/PKA/CREB pathway; Memory formation; Rat hippocampus.
Resumo: | Training in step-down inhibitory avoidance (0.3-mA footshock) is followed by biochemical changes in rat hippocampus that strongly suggest an involvement of quantitative changes in glutamate AMPA receptors, followed by changes in the dopamine D1 receptor/cAMP/protein kinase A (PKA)/CREB-P signalling pathway in memory consolidation. AMPA binding to its receptor and levels of the AMPA receptor-specific subunit GluR1 increase in the hippocampus within the first 3 h after training (20-70%). Binding of the specific D1 receptor ligand, SCH23390, and cAMP levels increase within 3 or 6 h after training (30-100%). PKA activity and CREB-P levels show two peaks: a 35-40% increase 0 h after training, and a second increase 3-6 h later (35-60%). The results correlate with pharmacological findings showing an early post-training involvement of AMPA receptors, and a late involvement of the D1/cAMP/PKA/CREB-P pathway in memory consolidation of this task
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000800008
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.8 1997
Fonte: | info:eu-repo/semantics/openAccess