Data/hora: 08/06/2024 11:22:06

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer
Autores: | Zhang,Y.; Chen,Q.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Ovarian cancer; Matrix metalloproteinases (MMPs); Tissue inhibitor of metalloproteinases (TIMPs); Invasion; Metastasis.
Resumo: | Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600301
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20176104
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.50 n.6 2017
Fonte: | info:eu-repo/semantics/openAccess