Data/hora: 09/06/2024 09:39:20

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Potential benefit of (-)-epigallocatechin-3-gallate for macrovascular complications in diabetes
Autores: | Tang,L.; Li,L.; Yang,J.; Zeng,C.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | (-)-Epigallocatechin-3-gallate; Diabetes; Macrovascular complications; Diabetes complications; Hypothesis.
Resumo: | Vascular problems are the most common complications in diabetes. Substantial evidence from epidemiological and pathophysiological studies show that hyperglycemia is a major risk factor for macrovascular complications in patients with diabetes. (-)-Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, is known to exert a variety of cardiovascular beneficial effects. The protective effects of EGCG in diabetes are also evident. However, whether EGCG is beneficial against macrovascular complications that occur in diabetes remains unknown. Our previous studies demonstrated that treatment of EGCG inhibits high glucose-induced vascular smooth muscle cell proliferation and suppresses high glucose-mediated vascular inflammation in human umbilical vein endothelial cells. Therefore, we hypothesize that EGCG might be an effective potential candidate to reduce the macrovascular complications in diabetes.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000401
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20176511
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.50 n.10 2017
Fonte: | info:eu-repo/semantics/openAccess