Data/hora: 08/06/2024 14:46:25

Provedor de dados: | 56
País: | Brazil
Título: | Effects of caffeine on learning and memory in rats tested in the Morris water maze
Autores: | Angelucci,M.E.M.; Cesário,C.; Hiroi,R.H.; Rosalen,P.L.; Cunha,C. Da.
Data: | 2002-10-01
Ano: | 2002
Palavras-chave: | Memory; Learning; Caffeine; Methylxanthines; Adenosine receptor antagonist; Morris water maze.
Resumo: | We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P&lt;=0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, P&lt;=0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002001000013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.10 2002
Fonte: | info:eu-repo/semantics/openAccess