Data/hora: 15/06/2024 19:43:19

Provedor de dados: | 56
País: | Brazil
Título: | Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection
Autores: | Souza,R.M.; Freitas,L.A.R.; Lyra,A.C.; Moraes,C.F.; Braga,E.L.; Lyra,L.G.C.
Data: | 2006-01-01
Ano: | 2006
Palavras-chave: | Hepatitis C infection; Iron overload; Genotype; Inflammatory activity; Fibrosis; Antiviral therapy.
Resumo: | The objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy. Liver tissue samples from 95 patients with chronic hepatitis C were divided into two groups: group I, presence of iron overload in hepatic tissue (Perls' staining) and group II, no iron overload. Hepatic iron overload was detected in 30 (31.6%) of 95 patients. Of the 69 patients tested by genotyping, 49 (71.01%) were genotype 1 and 20 (28.99%) genotype non-1. Iron overload was detected in 14 (28.6%) patients with genotype 1 and in 6 (30%) with genotype non-1 (P = 0.906). There was a significant difference in fibrosis stage between groups (P = 0.005). In group I (N = 30), one patient had stage F0/F1 of fibrosis, while in group II (N = 65), 22 (33.8%) patients had minimal or no fibrosis. Fibrosis stage F2/F3 was observed in 70% of group I patients compared to 46.2% of group II. Eighty-five patients were treated with a combination of interferon and ribavirin; 29 of them (34.1%) had a sustained virologic response and 8 (27.6%) of them had hepatic iron overload. Iron overload was detected in 18 (32.1%) of the 56 non-responders (P = 0.73). Hepatic iron overload was frequent among patients with chronic hepatitis C and was associated with a more severe stage of liver fibrosis. There was no association between iron overload and HCV genotype and response to interferon and ribavirin therapy.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100009
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006000100009
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.39 n.1 2006
Fonte: | info:eu-repo/semantics/openAccess