Data/hora: 30/05/2024 17:59:27

Provedor de dados: | 56
País: | Brazil
Título: | Compound 48/80, a histamine-depleting agent, blocks the protective effect of morphine against electroconvulsive shock in mice
Autores: | Karadag,C.H.; Dokmeci,D.; Dost,T.; Ulugol,A.; Dokmeci,I.
Data: | 2000-03-01
Ano: | 2000
Palavras-chave: | Morphine; Anticonvulsive effect; Histamine; Mast cells; Compound 48/80; Electroshock.
Resumo: | We have shown that morphine has an anticonvulsive effect against maximal electroconvulsive shock (MES) in mice, and this effect is antagonized by histamine H1-receptor antagonists. Brain histamine is localized both in neurons and in mast cells, and morphine is known to enhance the turnover of neuronal histamine and to release histamine from mast cells. In the present experiments, compound 48/80 was injected chronically (0.5 mg/kg on day 1, 1 mg/kg on day 2, 2 mg/kg on day 3, 3 mg/kg on day 4, and 4 mg/kg on day 5, twice daily, ip) to deplete mast cell contents. Morphine (0.001-10 mg/kg, ip; N = 20) produced a dose-dependent anticonvulsive effect against MES seizure in mice with non-depleted mast cells, whereas it did not exert any anticonvulsive effect in mice with depleted mast cells. These results indicate that morphine produces its anticonvulsive effect against maximal electroconvulsive shock in mice by liberating histamine from mast cells.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000300011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.3 2000
Fonte: | info:eu-repo/semantics/openAccess