Data/hora: 04/06/2024 18:32:02

Provedor de dados: | 56
País: | Brazil
Título: | C-reactive protein in acute coronary syndrome: association with 3-year outcomes
Autores: | Schaan,B.D.; Pellanda,L.C.; Maciel,P.T.; Duarte,E.R.; Portal,V.L.
Data: | 2009-12-01
Ano: | 2009
Palavras-chave: | Acute coronary syndromes; Inflammatory markers; C-reactive protein; Major cardiovascular events; Mortality.
Resumo: | Inflammatory markers have been associated with clinical outcome in patients with acute coronary syndrome (ACS). The present study evaluated the role of high-sensitivity C-reactive protein (CRP) measurements as a predictor of late cardiovascular outcomes after ACS. One hundred and ninety-nine ACS patients in a Coronary Care Unit from March to November 2002 were included and were reassessed clinically after ~3 years. Clinical variables and CRP levels were evaluated as predictors of major cardiovascular events (MACE, defined as the occurrence of cardiac death, ischemic stroke or myocardial infarction) and mortality. Statistical analyses included Cox multivariable analysis and survival curves (Kaplan-Meier). Of the 199 patients, 11 died within 1 month (5.5%). Of the 188 remaining patients, 22 died after a mean follow-up of 2.9 ± 0.5 years. Baseline CRP levels for patients with MACE (N = 57) were significantly higher than those of patients with no events (median = 0.67 mg/L; 25th-75th percentiles = 0.32 and 1.99 mg/L vs median = 0.45 mg/L; 25th-75th percentiles = 0.24 and 0.83 mg/L; P &lt; 0.001). Patients with CRP levels &gt;3 mg/L had a significantly lower survival than the other two groups (1-3 and &lt;1 mg/L; P = 0.001, log-rank test). The odds ratio for MACE was 7.41 (2.03-27.09) for patients with CRP &gt;3 mg/L compared with those with CRP &lt;1 mg/L. For death by any cause, the hazard ratio was 4.58 (1.93-10.86). High CRP levels predicted worse long-term outcomes (MACE and death by any cause) in patients with ACS.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200019
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2009007500016
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.42 n.12 2009
Fonte: | info:eu-repo/semantics/openAccess