Data/hora: 12/06/2024 07:52:58

Provedor de dados: | 56
País: | Brazil
Título: | Effect of injection of L-NAME on drinking response
Autores: | Saad,W.A.; Camargo,L.A.A.; Saad,R.; Pereira,A.F.; Simões,S.
Data: | 1999-11-01
Ano: | 1999
Palavras-chave: | Nitric oxide; Water intake; SFO; Dehydration; CNS.
Resumo: | The drinking behavior responses to centrally administered NG-nitro-L-arginine methyl ester (L-NAME; 10, 20 or 40 µg/µl), an inhibitor of nitric oxide synthase, were studied in satiated rats, with cannulae stereotaxically implanted into the lateral ventricle (LV) and subfornical organ (SFO). Water intake increased in all animals after angiotensin II (ANG II) injection into the LV, with values of 14.2 ± 1.4 ml/h. After injection of L-NAME at doses of 10, 20 or 40 µg/µl into the SFO before injection of ANG II (12 ng/µl) into the LV, water intake decreased progressively and reached basal levels after treatment with 0.15 M NaCl and with the highest dose of L-NAME (i.e., 40 µg). The water intake obtained after 40 µg/µl L-NAME was 0.8 ± 0.01 ml/h. Also, the injection of L-NAME, 10, 20 or 40 µg/µl, into the LV progressively reduced the water intake induced by hypertonic saline, with values of 5.3 ± 0.8, 3.2 ± 0.8 and 0.7 ± 0.01 ml/h, respectively. These results indicate that nitric oxide is involved in the regulation of drinking behavior induced by centrally administered ANG II and cellular dehydration and that the nitric oxide of the SFO plays an important role in this regulation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100012
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999001100012
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.11 1999
Fonte: | info:eu-repo/semantics/openAccess