Data/hora: 04/06/2024 01:36:25

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment	
Autores: 	Rudd,T.R.; Hughes,A.; Holman,J.; Solari,V.; de Oliveira Ferreira,E.; Cavalcante Pilotto Domingues,R.M.; Yates,E.A.	
Data: 	2012-05-01	
Ano: 	2012	
Palavras-chave: 	Heparan sulfate; Biosynthesis; Structure-function; Microbial attachment.	
Resumo: 	Heparan sulphate (HS) and the related polysaccharide, heparin, exhibit conformational and charge arrangement properties, which provide a degree of redundancy allowing several seemingly distinct sequences to exhibit the same activity. This can also be mimicked by other sulphated polysaccharides, both in overall effect and in the details of interactions and structural consequences of interactions with proteins. Together, these provide a source of active compounds suitable for further development as potential drugs. These polysaccharides also possess considerable size, which bestows upon them an additional useful property: the capability of disrupting processes comprising many individual interactions, such as those characterising the attachment of microbial pathogens to host cells. The range of involvement of HS in microbial attachment is reviewed and examples, which include viral, bacterial and parasitic infections and which, in many cases, are now being investigated as potential targets for intervention, are identified.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500002	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2012007500048	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.45 n.5 2012	
Fonte: 	info:eu-repo/semantics/openAccess