Data/hora: 16/06/2024 00:36:22

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Upregulation of microRNA 142-3p in the peripheral blood and urinary cells of kidney transplant recipients with post-transplant graft dysfunction	
Autores: 	Domenico,T.D.; Joelsons,G.; Montenegro,R.M.; Manfro,R.C.	
Data: 	2017-01-01	
Ano: 	2017	
Palavras-chave: 	MicroRNA; Graft dysfunction; Renal transplantation; Gene expression; Biomarker.	
Resumo: 	We analyzed microRNA (miR)-142-3p expression in leucocytes of the peripheral blood and urinary sediment cell samples obtained from kidney transplant recipients who developed graft dysfunction. Forty-one kidney transplant recipients with kidney graft dysfunction and 8 stable patients were included in the study. The groups were divided according to histological analysis into acute rejection group (n=23), acute tubular necrosis group (n=18) and stable patients group used as a control for gene expression (n=8). Percutaneous biopsies were performed and peripheral blood samples and urine samples were obtained. miR-142-3p was analyzed by real-time polymerase chain reaction. The group of patients with acute tubular necrosis presented significantly higher expressions in peripheral blood (P&lt;0.05) and urine (P&lt;0.001) compared to the stable patients group. Also, in the peripheral blood, miR-142-3p expression was significantly higher in the acute tubular necrosis group compared to the acute rejection group (P&lt;0.05). Urine samples of the acute rejection group presented higher expression compared to the stable patients group (P&lt;0.001) but the difference between acute tubular necrosis and acute rejection groups was not significant in the urinary analyzes (P=0.079). miR-142-3p expression has a distinct pattern of expression in the setting of post-operative acute tubular necrosis after kidney transplantation and may potentially be used as a non-invasive biomarker for renal graft dysfunction.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400605	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431x20175533	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.50 n.4 2017	
Fonte: 	info:eu-repo/semantics/openAccess