Data/hora: 28/05/2024 17:33:17

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC
Autores: | Bayeux,M.C.; Fernandes,A.T.; Foglio,M.A.; Carvalho,J.E.
Data: | 2002-10-01
Ano: | 2002
Palavras-chave: | Cordia curassavica; Cordia verbenaceae; Antiedematogenic; Anti-inflammatory; Medicinal plants.
Resumo: | The species Cordia curassavica (Boraginaceae), known popularly as "erva baleeira", is used in folk medicine for the treatment of several inflammatory processes and as a healing agent. The objective of the present study was to evaluate the antiedematogenic activity of crude dichloromethane extracts of Cordia curassavica and of the artemetin-enriched fraction. The crude extract and artemetin fraction were tested in the model of carrageenin-induced paw edema in male Swiss mice (25-30 g). The crude dichloromethane extract (300 and 1000 mg/kg, po, N = 6) showed significant antiedematogenic activity, reducing the edema by 42, 57 and 45% and 46, 62 and 69%, 3, 4 and 5 h after carrageenin administration, respectively. Indomethacin (10 mg/kg, po, N = 6) reduced the edema by 45 and 48%, after 4 and 5 h, but the artemetin-enriched fraction (30, 100 and 300 mg/kg, po, N = 6) had no activity. The dichloromethane extract (300 and 1000 mg/kg, po, N = 6) also showed antinociceptive activity by reducing acetic acid-induced writhing in mice from 37.1 ± 2.28 (control) to 17.3 ± 1.34 and 13.2 ± 1.44, respectively, but had no activity in the hot-plate test.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000017
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002001000017
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.10 2002
Fonte: | info:eu-repo/semantics/openAccess