Data/hora: 05/06/2024 00:40:44

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Endogenous vasopressin and the central control of heart rate during dynamic exercise
Autores: | Michelini,L.C.
Data: | 1998-09-01
Ano: | 1998
Palavras-chave: | Exercise tachycardia; V1 receptors; Brainstem areas; Peptides; Blood pressure; Training; Rats.
Resumo: | The present article contains a brief review on the role of vasopressinergic projections to the nucleus tractus solitarii in the genesis of reflex bradycardia and in the modulation of heart rate control during exercise. The effects of vasopressin on exercise tachycardia are discussed on the basis of both the endogenous peptide content changes and the heart rate response changes observed during running in sedentary and trained rats. Dynamic exercise caused a specific vasopressin content increase in dorsal and ventral brainstem areas. In accordance, rats pretreated with the peptide or the V1 blocker into the nucleus tractus solitarii showed a significant potentiation or a marked blunting of the exercise tachycardia, respectively, without any change in the pressure response to exercise. It is proposed that the long-descending vasopressinergic pathway to the nucleus tractus solitarii serves as one link between the two main neural controllers of circulation, i.e., the central command and feedback control mechanisms driven by the peripheral receptors. Therefore, vasopressinergic input could contribute to the adjustment of heart rate response (and cardiac output) to the circulatory demand during exercise.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900012
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000900012
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.9 1998
Fonte: | info:eu-repo/semantics/openAccess