Data/hora: 10/06/2024 03:44:31

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Effect of eccentric training on mitochondrial function and oxidative stress in the skeletal muscle of rats
Autores: | Silva,L.A.; Bom,K.F.; Tromm,C.B.; Rosa,G.L.; Mariano,I.; Pozzi,B.G.; Tuon,T.; Stresck,E.L.; Souza,C.T.; Pinho,R.A.
Data: | 2013-01-01
Ano: | 2013
Palavras-chave: | Eccentric training; Mitochondrial enzyme activity; Oxidative stress; Muscle damage; Inflammation.
Resumo: | The objective of the present study was to investigate the effects of eccentric training on the activity of mitochondrial respiratory chain enzymes, oxidative stress, muscle damage, and inflammation of skeletal muscle. Eighteen male mice (CF1) weighing 30-35 g were randomly divided into 3 groups (N = 6): untrained, trained eccentric running (16°; TER), and trained running (0°) (TR), and were submitted to an 8-week training program. TER increased muscle oxidative capacity (succinate dehydrogenase and complexes I and II) in a manner similar to TR, and TER did not decrease oxidative damage (xylenol and creatine phosphate) but increased antioxidant enzyme activity (superoxide dismutase and catalase) similar to TR. Muscle damage (creatine kinase) and inflammation (myeloperoxidase) were not reduced by TER. In conclusion, we suggest that TER improves mitochondrial function but does not reduce oxidative stress, muscle damage, or inflammation induced by eccentric contractions.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000100014
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20121956
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.46 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess