Data/hora: 10/06/2024 18:49:05

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
Autores: | Luna,R.C.P.; de Oliveira,Y.; Lisboa,J.V.C.; Chaves,T.R.; de Araújo,T.A.M.; de Sousa,E.E.; Miranda Neto,M.; Pirola,L.; Braga,V.A.; de Brito Alves,J.L.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Epigenetic; Pulmonary arterial hypertension; DNA Methylation; Histone acetylation; MiRNAs.
Resumo: | Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20187437
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.51 n.12 2018
Fonte: | info:eu-repo/semantics/openAccess