Data/hora: 08/06/2024 05:02:00

Provedor de dados: | 56
País: | Brazil
Título: | Distribution of AMPA-type glutamate receptor subunits in the chick visual system
Data: | 1997-01-01
Ano: | 1997
Palavras-chave: | Glutamate; Receptors; Neurotransmitters; Visual system; Visual pathways.
Resumo: | Several glutamate receptor (GluR) subunits have been characterized during the past few years. In the present study, subunit-specific antisera were used to determine the distribution of the AMPA-type glutamate receptor subunits GluR1-4 in retinorecipient areas of the chick brain. Six white leghorn chicks (Gallus gallus, 7-15 days old, unknown sex) were deeply anesthetized and perfused with 4% buffered paraformaldehyde and brain sections were stained using immunoperoxidase techniques. The AMPA-type glutamate receptor subunits GluR1, GluR2/3 and GluR4 were present in several retinorecipient areas, with varying degrees of colocalization. For example, perikarya in layers 2, 3, and 5 of the optic tectum contained GluR1, whereas GluR2/3 subunits appeared mainly in neurons of layer 13. The GluR4 subunit was only detected in a few cells of the tectal layer 13. GluR1 and GluR2/3 were observed in neurons of the nucleus geniculatus lateralis ventralis, whereas GluR4 was only present in its neuropil. Somata in the accessory optic nucleus appeared to contain GluR2/3 and GluR4, whereas GluR1 was the dominant subunit in the neuropil of this nucleus. These results suggest that different subpopulations of visual neurons might express different combinations of AMPA-type GluR subunits, which in turn might generate different synaptic responses to glutamate derived from retinal ganglion cell axons
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000100012
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000100012
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.1 1997
Fonte: | info:eu-repo/semantics/openAccess