Data/hora: 10/06/2024 13:47:14

Provedor de dados: | 56
País: | Brazil
Título: | Overexpression of ezrin and galectin-3 as predictors of poor prognosis of cervical cancer
Autores: | Li,M.; Feng,Y.M.; Fang,S.Q.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Ezrin protein; Galectin-3 protein; Cervical cancer; Deep myometrial invasion; Lymph node metastasis; Prognosis.
Resumo: | The aim of this study was to explore the correlation of ezrin and galectin-3 expressions with prognosis in cervical cancer. The immunohistochemical method was applied to detect ezrin and galectin-3 expressions in normal cervix tissues (n=30), cervicitis tissues (n=28), cervical intraepithelial neoplasia (CIN) tissues (classified as I-III, n=89), and cervical carcinoma tissues (n=84). Follow-up was conducted for 5 to 78 months to analyze the correlation of protein expressions with prognosis. Ezrin and galectin-3 expressions in cervical cancer were significantly higher than in normal cervix, cervicitis and CIN (all P&lt;0.05), and expressions in CIN were significantly higher than in normal cervix and cervicitis (both P&lt;0.05). The expressions of ezrin and galectin-3 were both related with histological grade, deep myometrial invasion and lymph node metastasis (all P&lt;0.05). Spearman analysis showed that ezrin expression was positively correlated with galectin-3 expression in cervical cancer (r=0.355, P&lt;0.05). The survival rate of patients with high expressions of ezrin and galectin-3 was significantly lower than those with low expressions of proteins (both P&lt;0.05). The expressions of ezrin and galectin-3, histological grade, depth of stromal invasion, and lymph node metastasis are risk factors affecting the survival rate of patients with cervical cancer. The expressions of ezrin and galectin-3 were correlated with the development of cervical cancer, and overexpressions of those proteins were indicative of poor prognosis in patients with cervical cancer.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400601
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20165356
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.50 n.4 2017
Fonte: | info:eu-repo/semantics/openAccess