Data/hora: 09/06/2024 05:52:19

Provedor de dados: 	56	
País: 	Brazil	
Título: 	MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients	
Autores: 	Siqueira,E.R.F.; Oliveira,C.P.M.S.; Correa-Giannella,M.L.; Stefano,J.T.; Cavaleiro,A.M.; Fortes,M.A.H.Z.; Muniz,M.T.C.; Silva,F.S.; Pereira,L.M.M.B.; Carrilho,F.J.	
Data: 	2012-01-01	
Ano: 	2012	
Palavras-chave: 	Hepatitis C; Steatosis; Fibrosis; Microsomal transfer protein.	
Resumo: 	The reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson’s disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the patients with fibrosis grade 3+4 presented at least one G allele versus 34.3% of the patients with fibrosis grade 1+2 (OR = 1.8; 95%CI = 1.3-2.3). Logistic regression analysis with steatosis as the dependent variable identified genotypes GG+GT as independent protective factors against steatosis (OR = 0.4, 95%CI = 0.2-0.8; P = 0.01). The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100012	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2011007500160	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.45 n.1 2012	
Fonte: 	info:eu-repo/semantics/openAccess