Data/hora: 13/06/2024 15:36:10

Provedor de dados: | 56
País: | Brazil
Título: | Relationship between microalbuminuria and cardiac structural changes in mild hypertensive patients
Autores: | Plavnik,F.L.; Silva,M.A.M.R.T.; Kohlmann,N.E.B.; Kohlmann Jr.,O.; Ribeiro,A.B.; Zanella,M.T.
Data: | 2002-07-01
Ano: | 2002
Palavras-chave: | Hypertension; Microalbuminuria; Left ventricular hypertrophy; Blood pressure monitoring.
Resumo: | The aim of this study was to determine the relationship between urinary albumin excretion (UAE), cardiac structural changes upon echocardiography and 24-h ambulatory blood pressure (ABPM) levels. Twenty mild hypertensive patients (mean age 56.8 ± 9.6 years) were evaluated. After 2 weeks of a washout period of all antihypertensive drugs, all patients underwent an echocardiographic evaluation, a 24-h ABPM and an overnight urine collection. Systolic and diastolic blood pressure during 24-h ABPM was 145 ± 14/91 ± 10 mmHg (daytime) and 130 ± 14/76 ± 8 mmHg (nighttime), respectively. Seven (35%) patients presented UAE  &gt; or = 15 µg/min, and for the whole group, the geometric mean value for UAE was 10.2 x/÷ 3.86 µg/min. Cardiac measurements showed mean values of interventricular septum thickness (IVS) of 11 ± 2.3 mm, left ventricular posterior wall thickness (PWT) of 10 ± 2.0 mm, left ventricular mass (LVM) of 165 ± 52 g, and left ventricular mass index (LVMI) of 99 ± 31 g/m². A forward stepwise regression model indicated that blood pressure levels did not influence UAE. Significant correlations were observed between UAE and cardiac structural parameters such as IVS (r = 0.71, P&lt;0.001), PWT (r = 0.64, P&lt;0.005), LVM (r = 0.65, P&lt;0.005) and LVMI (r = 0.57, P&lt;0.01). Compared with normoalbuminuric patients, those who had microalbuminuria presented higher values of all cardiac parameters measured. The predictive positive and negative values of UAE  &gt; or = 15 µg/min for the presence of geometric cardiac abnormalities were 75 and 91.6%. These data indicate that microalbuminuria in essential hypertension represents an early marker of cardiac structural damage.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700006
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002000700006
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.7 2002
Fonte: | info:eu-repo/semantics/openAccess