Data/hora: 10/06/2024 13:47:28

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Evaluation of the immune humoral response of Brazilian patients with Rubinstein-Taybi syndrome
Autores: | Sugayama,S.M.M.; Arslanian,C.; Sales,M.M.; Carneiro-Sampaio,M.
Data: | 2010-12-01
Ano: | 2010
Palavras-chave: | Rubinstein-Taybi syndrome; High IgM levels; B lymphocyte; Antibody response.
Resumo: | Rubinstein-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes, mental and growth deficiency, and recurrent respiratory infections. RTS has been associated with CREBBP gene mutations, but EP300 gene mutations have recently been reported in 6 individuals. In the present study, the humoral immune response in 16 RTS patients with recurrent respiratory infections of possible bacterial etiology was evaluated. No significant differences between patients and 16 healthy controls were detected to explain the high susceptibility to respiratory infections: normal or elevated serum immunoglobulin levels, normal salivary IgA levels, and a good antibody response to both polysaccharide and protein antigens were observed. However, most patients presented high serum IgM levels, a high number of total B cell and B subsets, and also high percentiles of apoptosis, suggesting that they could present B dysregulation. The CREBBP/p300 family gene is extremely important for B-cell regulation, and RTS may represent an interesting human model for studying the molecular mechanisms involved in B-cell development.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2010007500119
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.43 n.12 2010
Fonte: | info:eu-repo/semantics/openAccess