Data/hora: 28/05/2024 15:18:49

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway
Autores: | Li,Jingrong; Fang,Ruihua; Wang,Jianqin; Deng,Liehua.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | Malignant melanoma; Metastasis; NOP14; Proliferation; Wnt/β-catenin pathway.
Resumo: | Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. In this study, we observed that malignant melanoma tissue showed NOP14 down-regulation compared to melanocytic nevi tissues. Moreover, we observed that NOP14 expression was significantly associated with melanoma tumor thickness and lymph node metastasis. NOP14 overexpression in melanoma cells suppressed proliferation, caused G1 phase arrest, promoted apoptosis, and inhibited melanoma cell migration and invasion. Further investigations revealed that NOP14 overexpression reduced the expression levels of Wnt3a, β-catenin, and GSK-3β of the Wnt/β-catenin pathway. In summary, we demonstrated that NOP14 inhibited melanoma cell proliferation and metastasis by regulating the Wnt/β-catenin signaling pathway.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100604
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20187952
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.52 n.1 2019
Fonte: | info:eu-repo/semantics/openAccess