Data/hora: 03/06/2024 05:24:16

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | The role of necroptosis in neurosurgical diseases
Autores: | Liu,T.; Bao,Y.H.; Wang,Y.; Jiang,J.Y.
Data: | 2015-04-01
Ano: | 2015
Palavras-chave: | Molecular mechanism; Pathogenesis; Programmed cell death; Therapy.
Resumo: | Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400292
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20144310
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.48 n.4 2015
Fonte: | info:eu-repo/semantics/openAccess