Data/hora: 08/06/2024 18:10:57

Provedor de dados: | 56
País: | Brazil
Título: | Implications of infectious diseases and the adrenal hypothesis for the etiology of childhood acute lymphoblastic leukemia
Autores: | Azevedo-Silva,F.; Camargo,B.de; Pombo-de-Oliveira,M.S.
Data: | 2010-03-01
Ano: | 2010
Palavras-chave: | Lymphoblastic leukemia; Childhood infections; Epidemiology; Kala-azar; Adrenal hypothesis.
Resumo: | Acute leukemia is the most frequent cancer in children. Recently, a new hypothesis was proposed for the pathogenesis of childhood acute lymphoblastic leukemia (ALL). The so-called "adrenal hypothesis" emphasized the role of endogenous cortisol in the etiology of B-cell precursor ALL. The incidence peak of ALL in children between 3 to 5 years of age has been well documented and is consistent with this view. The adrenal hypothesis proposes that the risk of childhood B-cell precursor ALL is reduced when early childhood infections induce qualitative and quantitative changes in the hypothalamus-pituitary-adrenal axis. It suggests that the increased plasma cortisol levels would be sufficient to eliminate all clonal leukemic cells originating during fetal life. Because Brazil is a continental and tropical country, the exposure to infections is diversified with endemic viral and regionally non-viral infections, with some characteristics that support the recent adrenal hypothesis. Here we discuss this new hypothesis in terms of data from epidemiological studies and the possible implications of the diversity of infections occurring in Brazilian children.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2010007500011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.43 n.3 2010
Fonte: | info:eu-repo/semantics/openAccess